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摘要: 本课题利用羟丙基-β-环糊精（HP-β-CD）外亲水内疏水的空腔结构特性，通过水溶液络合法对薄荷脑进行包合，运用单因素实验，考察了薄荷脑与羟丙基-β-环糊精的比例、干燥温度等因素如何影响羟丙基-β-环糊精与薄荷脑的包结能。由此得出包埋方法的不同，干燥温度的区别等因素会直接导致包埋效果的差异。用羟丙基-β-环糊精将薄荷脑制备成包合物，既可以避免薄荷脑的挥发损失，又能提高其稳定性。薄简脑包合物制备方法和脱包方法已有报道，但这些研究都处于实验探讨阶段。根据单因素法来进行实验，来确定最佳的包合工艺参数，用热重分析，红外光谱和XRD对其包结率进行测定，并对水浴法和超声波法两种脱包方法进行比较，为羟丙基-β-环糊精包合物的规模化生产提供参考。35541
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毕业论文关键词: 羟丙基-β-环糊精；包结能；薄荷脑；
The Study of the Inclusion Energy of hydroxypropyl-β-cyclodextrin and Menthol
Abstract: Because hydroxypropyl-β-cyclodextrins(HP-β-CD) has a hydrophobic cavity structure inside , it was used to embed menthol by a aqueous solution complex method. It was investigated by single factor experiment that the influence of the mass ratio between menthol and hydroxypropyl-β-cyclodextrins,the temperature of drying an other factors affect the Inclusion Energy of hydroxypropyl-β- cyclodextrin with menthol.It can avoid the losing of menthol and improve the stability of menthol that menthol is loaded into hydroxypropyl-β-cyclodextrins.It was reported how to make this thing,but those studys are all in the stage of experimental investigation.The best way to load menthol into hydroxypropyl-β-cyclodextrins was investigated by single factor experiment .The rate of Inclusion is measured by Thermogravimetric Analysis, (Infrared Spectroscopy and X-ray diffraction.Comparing the method water-bath with ultrasonic method,wo can give a reference to produce it.
Key words: hydroxypropyl-β-cyclodextrins；Inclusion； Menthol
目录
1绪论 1
1.1本课题国内外研究现状 1
1.1.1 β-环糊精及其衍生物的研究 1
1.1.2 HP-β-CD的结构与性能特点 2
1.1.3 羟丙基-β-环糊精（HP-β-CD）应用进展 2
1.1.4性状描述 4
1.2 羟丙基-β-环糊精的结构 4
1.3羟丙基-β-环糊精包结香精的机理 5
2 材料与方法 6
2.1 材料与设备 6
2.1.1 材料与试剂 6
2.1.2 实验仪器及设备 6
2.2 实验方法 6
2.2.1 实验原理 6
2.2.2 实验工艺 7
2.2.2.1 羟丙基-β-环糊精溶液的制备 7
2.2.2.2 羟丙基-β-环糊精和薄荷脑的包结物的制备 7
2.2.2.2.1水浴法 7
2.2.2.2.2超声波法 7
2.2.2 热重的测试 8
2.2.3 红外的测试 8
2.2.4 XRD的测试 8
3 结果与讨论 10
3.1羟丙基-β-环糊精，薄荷脑及其包结物的红外光谱分析 10
3.2羟丙基-β-环糊精，薄荷脑及其包结物的XRD分析 15
3.3羟丙基-β-环糊精，薄荷脑及其包结物热重分析 15
3.3. 1羟丙基-β-环糊精空白对照样品 15
3.3. 2薄荷脑的热重分析 18