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设计总说明间甲酚是无色带有黄色的可燃液体，是树脂、医药、染料、农药、彩色胶片、香料的重要中间体，例如：染料C．I．、文生素E、农药除虫菊酯、传真用复印纸等。据资料统计，间甲酚的需求量一直将保持年均7％～10％左右的高速增长，目前产量不能满足国内市场需求，每年都需要进口相当数量的间甲酚。随着人们对精细化学品的开发和研究，间甲酚的用处越来越广泛，需求量越来越大。36029
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间甲酚的合成工艺有四种成熟的实验室合成方法。经过反复比较和确认，本设计最终采用工业化可行性和可操作性最大的间甲苯胺重氮化法。并以此工艺路线为基准开发并转化为实际工业生产过程。
采用现在市场中方便易得的工艺生产所需的原料，确定物料来源、价格和规格等，确定每种原料及最终成品的物性数据等。并利用邻硝基苯乙酸的工艺研究中的确定的最佳工艺参数：间甲苯胺、亚硝酸钠、硫酸以摩尔比例：1：1．01：3；最适反应温度为5℃等，开发一个间甲苯胺新的用于工业生产的工艺过程。并进行物料和能量衡算。进而根据能量衡算确定生产过程使用的设备型号。
根据国家对化工企业生产的一系列要求，开发并设计适用于实际生产的工艺流程和设备布置图。
毕业论文关键词：间甲酚；重氮化；工业生产；
Design Specification
M-cresol is a colorless to yellow flammable liquid, is an important intermediates of dyestuff, medicine, pesticide, color film, resin, aromatics, such as dye (C.I., vitamin E, pesticide intends to pyrethroids, fax, copy paper. According to statistics, m-cresol demand will remain at an average annual rate of 8% ~ 10% of high-speed growth, the production can not meet the needs of the domestic market year needs to be a considerable quantity of imports of m-cresol. With the research and development of fine chemicals, m-cresol use more and more widely, more and more demand.
The synthesis process of m-cresol has four kinds of mature methods of laboratory synthesis. After comparison and confirmation, the design of the final use of the industrialization of the largest and operability of the maximum between the aniline re - nitride method. And taking this process route as the datum development and into the actual industrial production process.
The raw materials, the price and the specifications of the materials used in the process of production are convenient, and the material properties of every raw material and the final product are determined..And the use of o-nitrobenzoic acid in the process of research of the determination of the optimal process parameters: between methyl aniline, sodium nitrate and sulfate on a molar ratio: 1:1.01:3; optimum reaction temperature of 5 DEG C, development a toluene amine new for industrial production process. And the material and energy balance calculation. And then, according to energy balance, the equipment used in the process of production is determined..
According to the national production of chemical enterprises, a series of requirements, development and design for the actual production process and equipment layout plan.
KeyWords：m-cresol；diazotization；Industrial production；
目 录
设计总说明… …Ⅰ
Design General Information… …Ⅱ
目录 …Ⅲ
1. 引言…1
1.1 选题的背景…1
1.2 本工艺设计的意义1
1.3 国内外间甲酚的合成工艺进2
1.3.1 混合甲酚分离法…2
1.3.2 异丙基甲苯法…2
1.3.3 邻二甲苯法3
1.3.4 间甲苯胺重氮化水解法…3
1.4 发展趋势…4
1.5 本工艺设计的内容4
2. 间甲苯胺重氮化水解法4
3. 原料来源与规格…5