摘要N-酰基氨基酸型表面活性剂是以生物物质为基础的表而活性剂具有良好的表 面性能，还可以用作防腐剂，并且同时具有优良的抗菌和抗毒的性能。因此对 N- 酰基氨基酸系列表面活性剂进行研究开发具有重要的意义。68557

该篇文章涉及同类型的化合物即 N-酰基氨基酸型表面活性剂的合成，用酰氯 和氨基酸（亮氨基酸，甘氨基酸，缬氨基酸，丙氨基酸）使用肖顿-鲍曼缩合反应 来制备。并完成了对合成该类化合物的肖顿-鲍曼反应在工艺条件上的改良优化。 肖顿-鲍曼缩合反应：脂肪酰氯和氨基酸摩尔比为 1:2，以 5～6 滴/分钟的速度滴加 脂肪酰氯，1mol/L 的 NaOH 用来调节溶液 pH、为缚酸剂（中和反应过程生成的 酸），控制反应体系的 pH 在 9 和 10 之间，在室温情况下滴加脂肪酰氯，反应进 行时的温度应维持在 25℃，反应历时 3 h。在此种反应条件的情况下，合成反应 的收率为 73.6％～85.4％。对合成的化合物的熔点、红外光谱、1H NMR 进行测 定，运用了这几种分析手段对所合成的物质进行了特征表征。

毕业论文关键词: N-酰基氨基酸,表面活性剂,肖顿-鲍曼缩合反应

Title Synthesis of N-acyl Gan amino acid surfactants

Abstract

N-acylamino acid type surface active agent is a biomass-based tables surface active agent having good properties, but also can be used as preservatives, and also has good antibacterial and antitoxic performance. So the N-acyl amino acid surfactants series research and development is of great significance.

This article relates to the synthesis of compounds of the same type that is type N-acyl amino acid surfactants, and amino acids with an acid chloride (bright acids, sweet amino acids valine, malonic acids) using Shotton - prepared Bowman condensation reaction. Shotton and completed the synthesis of these compounds - Improved optimization Baumann reaction on the process conditions.Shotton - Bowman condensation reaction: aliphatic amino acid chloride molar ratio of 1:2 and a rate of 5-6 drops per minute fatty acid chloride was added dropwise, 1mol / L solution of NaOH to adjust the pH, the acid binding agent (in and acid generated during the reaction), the

reaction system to control the pH between 9 and 10, in the case of 15 ℃ fatty acid

chloride was added dropwise, while the reaction temperature should be maintained at 25 ℃, the reaction lasted for 3 h. Under such reaction conditions, the yield of the synthesis reaction to 85.4% and 73.6%. Then I re-order analysis of the structure of the

product of the melting point of the synthesized compounds, IR, 1H NMR, 13C NMR were measured, using the means of the analysis of these types of synthetic substances characteristic characterization.

Keywords :N-acyl amino acid，surfactants，Shotton-Bowman condensations

目次

1  文献综述 1

1.1  前言 1

1.2  氨基酸表面活性剂结构分类 1

1.3  合成方法 4

1.4 N-酰基氨基酸型表面活性剂的性质和应用开发 6

2  实验条件和反应机理 7

2.1  实验条件 8

2.2 合成路线及作用机理 9

3  实验部分 11

3.1 实验合成步骤 11

3.2  产物结构的表征