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At present, study on the synthesis of our country for pranlukast has just started, the important intermediate 2- hydroxy -3- Aminoacetophenonehydrochloride Market demand is rising. Research about the intermediate bulksynthesis reported less, market sales of 2- hydroxy -3- Aminoacetophenonehydrochloride prices higher, far can not meet the needs of the market.Therefore, finding a low cost, green environmental protection, high yield, have very important significance of 2- hydroxy -3- Aminoacetophenonehydrochloride synthesis route and suitable for industrial production.
The design is based on 5- chloro 2- hydroxy acetophenone, fuming nitric acid,hydrochloric acid, hydrogen as raw materials, process design of 10%Pd-Ccatalyst for an annual output of 100 tons of 2- hydroxy -3- aminoacetophenone hydrochloride.
This paper introduces the properties and uses of 2- hydroxy -3-Aminoacetophenone hydrochloride, application prospect, a comprehensive comparison of the latest research progress of 2- hydroxy -3-Aminoacetophenone hydrochloride, in considering the factors of product yield,process maturity degree, determine the 10%Pd-C as catalysts for the synthesis of 2- hydroxy -3- amino benzene ethyl ketone hydrochloride. The total yield of the design scheme of 2- hydroxy -3- Aminoacetophenonehydrochloride reached 89.2%.
Firstly, according to the 2- hydroxy -3- Aminoacetophenone hydrochloride test results, reference to domestic and foreign literature record, determining the reasonable process for synthesis of 2- hydroxy -3- Aminoacetophenone hydrochloride.
According to the process of technological design, and the operation unit of material balance, the each unit operation and the amount of material and the whole process of the raw materials consumption quota. In the process of heat exchanging system involved were carried out to determine the heat balance, heat exchange area and heating steam, cooling water, chilled water consumption quota.
Combining the material balance, heat balance and process design, selection of the main equipment used for the process specifications; nitration reactor, hydrodehalogenation kettle and the volume and specification Shiogama calculating, according to material properties and operating conditions of the equipment material selection.
Based on process calculation and design results, draw the construction technics flow chart.
In consideration of convenient operation, convenient transportation, reduce the bearing of buildings, factory building, design the schematic diagram and the floor equipment plane layout, drawing process equipment layout.
Keyword:5-chloro-2-hydroxy Acetophenone,2-hydroxy-3-Aminoacetophenone hydrochloride,small scale
目录
1.绪论 1
1.1产品性质 1
1.2普仑司特 1
1.3原料及中间体的理化性质 4
1.4设计依据 5
2.物料衡算 12
2.1硝化反应 12
2.2加氢脱卤反应 12
2.3成盐反应 13
3.热量衡算 15
3.1硝化反应能量衡算 15
3.2加氢脱卤工段的能量衡算 18
3.3成盐工段能量衡算 20
4.部分设备的选型及计算 23
4.1 釜 23
4.2 辅助设备计算与选型 24
4.3泵 26
5. 非工艺部分 27
5.1 车间布置 27
(一)硝化反应釜装配图(见附录一) 27
(二)工艺流程图(见附录二) 27
(三)生产车间平面布置图(见附录三) 27
5.2 车间的布置设计 27
5.3 设备间的距离 27
5.4 安全和防腐要求 27
5.5 土建及房屋建筑 28