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摘要：我国目前一硝基甲苯及其衍生物的开发发展迅速，产品价格低，在国际上很有竞争力。由甲苯硝化合成一硝基甲苯（邻硝基甲苯、间硝基甲苯、对硝基甲苯＝60:4:36），其中邻硝基甲苯的比例最大，但是市场上对硝基甲苯的需求量较大，这就造成邻硝基甲苯生产的过剩。邻硝基苯乙酸是一种具有广泛用途的有机中间体，其传统的合成方法原料（邻硝基苯乙腈）不易得到。因此研究以邻硝基甲苯为原料来合成邻硝基苯乙酸的工艺具有很高的实用价值。
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邻硝基苯乙酸是一种重要的有机合成中间体，在精细化工产品生产中应用广泛，它本身也是很好的除草剂。由于邻硝基甲苯生产的相对过剩，因而开发一种比较廉价和环保的以邻硝基甲苯为原料合成邻硝基苯乙酸的方法就有其必要性和实用性。
本设计采用邻硝基甲苯与草酸二乙酯为原料，在乙醇钠催化下缩合，然后经水解、双氧水氧化脱羧、酸化得到邻硝基苯乙酸。设计的重点主要在：工艺流程设计，物料衡算，热量衡算，设备工艺设计与选型及车间布置设计。5632
关键词： 邻硝基苯乙酸；邻硝基甲苯；缩合；氧化
Workshop Process Design of 200t/a
o-Nitrophenylacetic Acid
Abstract：At present, the nitrotoluene and its derivatives develop fast and are very competitive in the world because of its low price. The synthesized proportion of o-nitrotoluene, m-nitrotolueneand p-nitrotoluene is 60:4:36 in the synthetic process ,and the synthetic proportion of o-nitrotoluene is the largest while the demand of p-nitrotoluen is great. Which causes the excessof o-nitrotoluene. The o-nitrophenylacetic acid is a kind of organic intermediate with wide usage, but the traditional synthetic materials（o-nitrophenylacetonitrile）are not easily obtained. So studying the synthetic thechnology of the o-nitrophenylacetic acid using the o-nitrotolueneas materials has great practical value.
The o-nitrophenylacetic acid is a kind of organic intermediate with wide usage, Widely used in fine chemical products production, it is itself a good herbicide. Due to o-Nitrophenylmethane production of relative surplus, so study in which a relatively cheap and environmentally o-Nitrophenylmethane as raw material to synthesis of o-Nitrophenylacetic acid method has its necessity and practicability.
Studies the method to synthesize the o-nitrophenylacetic acid, that is the o-nitrotoluene and diethyl oxalate are condensed under the catalysis of sodium ethoxide, and then the o-nitrophenylacetic acid is obtained through many processes, such as hydrolysis and oxidation and extraction and acidification . Design of focused primarily at: the whole process of material balance, caloric, equipment design and selection, process design and layout design workshop.
KeyWords：o-Nitrophenylacetic acid；o-Nitrophenylmethane；condensation； oxidation
目录
1概述..1
1.1设计项目名称1
1.2设计依据与原则..1
1.3产品概述..1
1.4工艺沿革..2
1.5产品、原料中间体的主要物化性质与规格4
1.5.1邻硝基苯乙酸..4
1.5.2邻硝基甲苯4
1.5.3草酸二乙酯5
1.5.4固体乙醇钠6
1.5.5无水乙醇.6
1.5.6液碱（工业氢氧化钠）.7
1.5.7工业过氧化氢..8
1.5.8固体碳酸钠8
1.5.9浓盐酸..9
2工艺流程设计..10
2.1生产工艺过程设计10
2.1.1生产工艺反应式.10
2.1.2过程条件简述..10
2.1.3 工艺流程框图.11
2.2带控制点的工艺流程图（见附录）
3工艺设计书.13
3.1物料衡算..13
3.1.1设计任务和依据.13
3.1.2物料衡算.13
3.2热量衡算..27
3.2.1计算基准.27
3.2.2氧化脱羧反应热量衡算.27
4工艺设备选型与设计计算.31
4.1设计方法与原则..31