2。 Design standard

This design has referred to below the national standard and the stipulation。

a。 Commonly used dangerous chemistry classified standard。 (GB13690-1992)

b。 Production process dangerous material and harmful factor classification and code。 (GB/T13816-1992)

c。 In pressure vessel chemistry medium model harm and explosion hazard degree classification。 (HGJ43-1991)

d。 The steel pins down the pressure vessel。 (GB150) 

e。 Shell type heat interchanger standard。 (GB151)

f。 Factory fire protection stipulation。 (GBJ16-1987)

g。 The sewage synthesis discharges the stipulation。 (GBJ8978)

h。 Craft system arrangement of equipment design stipulation。 (HG20570)

i。 Chemical installment piping arrangement design stipulation。 (HG/T20549)

3。 Principle of design and main design standard

Principle:

(1) Safe: In the chemical production the massive matter are flammable, explosive or are virulent。 Therefore, the design must fully think about everything is obvious and the latent danger, the guarantee production personnel’s health and the security。

(2) Ease of operation: At the same time, in determining the various production processes and equipment, but also a reasonable determination of operating conditions。 Because it is the production process and equipment to be established and it’s a important role in the play and controlling the programs, having a direct relationship。 

(3) Investment province: Namely the request economically uses the equipment investment, the construction invests, the public project investment and the manpower cost。

(4) Is advantageous for the installment: The factory arrangement should satisfy the construction and the installment work request。 Specially should consider the large-scale equipment the hoisting, in the factory the path pavement structure and the load standard and so on should satisfy the work the request。

Key words：Aceclofenac; diclofenac; design; reactor

目 录

1 概述 1

1。1 设计项目名称 1

1。2 生产规模 1

1。3 产品说明 1

1。4 原料及中间体的主要用途、理化性质、规格 1

1。5 设计依据 5

2 生产车间工艺流程设计 7

2。1 生产工艺的选择 7

2。2 物料流程框图 7

2。3 各工段产品指标 7

3 生产车间工艺计算 9

3。1 物料平衡计算 10

3。1。1 投料计算 10

3。1。2 取代反应物料衡算 10

3。1。3 酯酸解反应物料衡算 12

3。1。4 总物料衡算 14

3。2