Abstract Proteins are one of the important substances that ensure the organisms normal activities, so that exploring the protein-protein interactions is one way to analyze the life activities。 In this article, firstly, we introduce some basic conceptions and demonstration methods about protein interactions on the macro。 And then we analyze some factors contributing to protein interactions on the micro, such as affinities。 To study the factors contributing to the protein interactions we use the MIC, one kind of MINE。 By this method, we need collect a lot of data and then rank them by a given standard。 Through the theoretical analysis, accompany with running software to calculate the relationships, we can deeper understanding the relationships between factors。 By this method, we can get a better understanding about protein interactions。
At the meantime, during the calculations, we find a lot of problems in the given data sets,which would cause errors in the analysis。 So the factors that continue to study the improvement derection is proposed。