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    Main technical data: check all relevant paracetamol production methods,market demand, production, function; consult relevant drug design workshop information. The documents may include: Chinese database three, Foreign Patent Office Web site, EBSCO and Springer Link electronic journal, SciFinder Scholar.
    Production method.:
    1 Acylation:90 ℃ -135 ℃ ;P-aminophenol:HAC=1:2.8(the mol compare)
     2 Cooling crystallization:90 ℃ -20 ℃
    3 Dissolution of decolorization:20 ℃ -110 ℃
    4 Filter press:The plank frame type presses to filter machine 630 ×s 630 BAS40-63 °s/25s
    5 Cooling structure:90 ℃ -20 ℃
    6 drying:The induced draft fan, air preheating and filtration, when the inlet air temperature up to 125 ℃, under pressure, open the feed mixer, when the inlet air temperature up to 135 ℃, the air temperature at 75 ℃, continuous feeding collected two stage cyclone separator in the "pink head" and then into the delicate section fine, the level in the separator barrel "powder", weighing
    7 sour liquids:20 ℃ -110 ℃
    8 sparse acetic acids recover:Recover a sour and congealed machine;Physical volume:5 ms 3;Specification:Graphite The inspissation of
    9 Concentrated liquor:90 ℃ -20 ℃
    Acetic acid: an important chemical raw material, can be prepared a variety of acetic acid derivatives such as acetic anhydride, chloroacetic acid, ethyl cellulose, suitable for the production of terephthalic acid, textile printing and dyeing, fermentation amino acid, but also as a fungicide; preparation method with ethanol, ethylene by oxidation, liquid phase oxidation of alkane aldehyde and methanol carbonylation. Can also be made by wood tar by solvent extraction separation.
    Sodium metabisulfite: used in the production of chloroform, benzene propyl sulfone and benzaldehyde in pharmaceutical industry, rubber industry as coagulant,printing and dyeing industry as cotton bleached dechlorination agent, cotton fabric scouring auxiliaries for leather processing, leather industry, the chemical industry for the production of hydroxyl vanillin, salt acid hydroxylamine, photographic industry as a developer;absorption of sulfur dioxide by soda solution.
    P-aminophenol: never take this medicine in the cold empty stomach large dose; forbidden to take this medicine after drinking; avoid also take two or more than two kinds of cold medicine containing acetaminophen; elderly patients the dose should be reduced by 30% ~ 40%; to avoid long-term use.
    目录
    1 工艺总述    1
    1.1 产品用途    1
    1.2 产品性能    1
    1.2.1 产品介绍    1
    1.2.2 理化性质    1
    1.2.3 产品质量规格    1
    1.2.4 产品包装方式    2
    1.3 原料及中间体介绍    2
    1.3.1 对氨基苯酚    2
    1.3.2 醋酸    2
    1.4 国内外市场综述    3
    1.4.1 国际市场    3
    1.4.2 国内市场    3
    1.4.3 我国发展建议    4
    1.5 扑热息痛合成工艺路线设计    4
    1.5.1 合成路线概述    4
    1.5.2 一步合成法    5
    1.5.3 二步合成法    5
    1.5.4 对氨基苯酚的合成方法和特点    6
    1.5.5 结论    6
    1.6  工艺流程    7
    1.6.1  酰化    7
    1.6.2  冷却结晶    7
    1.6.3  溶解脱色    7
    1.6.4  压滤    7
    1.6.5  冷却结晶    7
    1.6.6  干燥    8
    1.6.7  酸母液的浓缩    8
    1.6.8  稀醋酸回收    8
    1.6.9  精母液的浓缩    8
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