摘要头孢拉定，别名：先锋霉素Ⅵ、头孢菌素Ⅵ等，是第一代头孢菌素类抗生素。由于头孢拉定耐酸，所以对胃酸稳定，它同时既可供口服，也可供注射使用。再加上头孢拉定抗菌谱广、抗菌能力强，以及对β-内酰胺酶耐受且具有口服吸收好、在体内血药浓度高等优点，头孢拉定成为了半合成头孢菌素中的重要品种之一。其临床上对多种感染具有明显的疗效，综其各优点，它不仅在人医临床应用上极为广泛，其在兽医临床上的价值近年来也得到行业认可，对于兽医临床也具有非常大的价值。于2012年，头孢拉定的胶囊剂、片剂正式列入了《国家基本药物品种》（2012版）。

本设计将根据原料药的物理化学性质以及其制备工艺，设计选择对其合适的辅料，设备及成型工艺，在设计工艺上，流程上，技术上，都对于产品质量能够符合国家相关规定，并在此基础上，能产生更大经济效应，同时对于环境、资源等产生更少影响的设计。本设计将以上海市奉贤区为厂址，根据当地的自然环境条件以及人为条件合理做出较优化的设计，同时满足并优于国家对药品生产所制定的各项法律法规。82109

毕业论文关键词：头孢拉定、车间工艺设计、平面布置图 

ABSTRACT Cephradine （alias: cephalotaxin Ⅵ, cephalosporin Ⅵ, etc。）, is the first generation of cephalosporin antibiotics。 Because of resisting acid, so it can be stable in gastric acid, it not only can be taken for oral, but also can be used by injecting。 Coupled with cefradine antibacterial spectrum, antibacterial ability, as well as β-lactamase tolerance and has good oral absorption, the advantages of high plasma concentration in the body, cephradine has become a semi-synthetic cephalosporins in one of the important varieties。 Its clinical manifestations of a variety of infections have a significant effect, its advantages, it is not only in clinical application of human medicine is extremely extensive, its clinical value in veterinary medicine in recent years has also been recognized by the industry, for veterinary clinical also has a very large value。 In 2012, cefradine capsules, tablets officially included in the "National Essential Drug Varieties" (2012 version)。

The design will be based on the physical and chemical properties of raw materials and its preparation process, design and selection of its appropriate accessories, equipment and molding process, in the design process, process, technically, for product quality to meet the relevant national regulations, and On this basis, can produce greater economic effects, while the environment, resources, etc。 have less impact on the design。 The design will be in Shanghai Fengxian District for the site, according to the local conditions of the natural environment and human conditions to make a more rational design, while meeting and better than the state of the drug production laws and regulations。

KEY WORDS: Cefradine，the preliminary process design，bulk drugs

目 录

摘 要 1

ABSTRACT 2

目 录 3

1 车间设计概述 6

1。1 制药车间设计的基本要求 6

1。2 制药车间设计的工作程序 6

1。3 制药车间设计的意义 7

2 生产工艺流程设计 8

2。1 概述