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摘要冬凌草甲素是一种有效的抗肿瘤药物，由于其水溶性较差等原因，使其应用受到限制。脂质体作为一种新型给药方式，成功的解除冬凌草甲素在应用上的限制，促进其在抗肿瘤作用上的发展，而叶酸受体能够使得脂质体具有主动地靶向性，制备的脂质体微气泡在超声的作用下能够促进包覆药物的释放，均使给药效率提高。本文制备了几种脂质体，即含或不含高分子材料FA-PEG2000-Chol、含或不含CO2和含或不含冬凌草甲素等脂质体，并测定各型脂质体的包封率及释放度，探索冬凌草甲素以脂质体作为药物载体的可行性，并探讨FA-PEG2000-Chol、CO2和超声对包封率和释放度的影响。22521
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关键词 叶酸受体 冬凌草甲素 脂质微泡 包封率 释放度
毕业论文设计说明书（论文）外文摘要
Title Construction of Folate Receptor-Mediated Liposome Microbubbles Coated With Oridonin And Research On Related Characteristics
Abstract
Oridonin is an effective anticancer drug, because of its poor water solubility and other reasons, its application is limited. Liposomes as a new route of drug delivery, have successfully removed the restrictions on oridonin application and promote its development on anticancer effect. Folate receptor can lead Liposome Microbubbles to have an active targeting. Ultrasound can promote the release effect of the drug coated in the liposome microbubbles. Efficiency were both increased. In this experiment, several types of lipsome microbubbles had been prepared. That is, whether containing the polymer material FA-PEG2000-Chol, whether containing CO2 and whether containing oridonin,and all of the encapsulation efficiency and release percents had been measured to grope for the feasibility of liposome microbubbles used as drug carriers for oridonin. And probe the influences of the encapsulation efficiency and release percents caused by FA-PEG2000-Chol, CO2 and ultrasound.
Key words Folate receptor; Oridonin; Liposome microbubbles; Encapsulation efficiency; Release percent
目 次
1 绪论 2
1.1 脂质体研究进展 2
1.1.1 脂质体的组成及分类 2
1.1.2 脂质体的制备方法 2
1.1.3 理想脂质体应具有的特点 3
1.1.4 脂质体应用前景 3
1.2 叶酸脂质体研究进展 4
1.2.1 叶酸受体概述 4
1.2.2 叶酸受体分类 4
1.2.3 叶酸脂质体特点 4
1.2.4 叶酸脂质体制备 4
1.2.5 叶酸脂质体介导肿瘤靶向治疗 4
1.3 脂质体微泡研究进展 5
1.3.1 脂质体微泡及填充气的选择 5
1.3.2 脂质体微泡制备方法 5
1.3.3 脂质体微泡应用 5
1.4 冬凌草甲素 6
1.4.1 冬凌草甲素的理化性质及衍生物 6
1.4.2 冬凌草甲素的药理作用 6
1.4.3 冬凌草甲素的应用 7
1.5 研究内容和主要研究方法 7
1.5.1 研究内容 7
1.5.2 研究方法 7
2 叶酸受体介导包覆冬凌草甲素脂质微气泡的构建 8
2.1 材料与实验仪器 8
2.1.1 仪器 8
2.1.2 材料 8
2.2 方法与结果 9
2.2.1 PBS缓冲液的配制 9
2.2.2 各种脂质体的制备 9