血卟啉环糊精包合物制备工艺研究
摘要研究血卟啉-环糊精包合物的制备工艺，以水溶性、载药量以及包封率为考察指标，优选出最佳环糊精作为包合材料，并采用研磨法和饱和水溶液法制备包合物，运用单因素试验法优选出最佳制备方法及工艺条件，通过紫外-可见吸收光谱法（UV-Vis），傅里叶红外光谱法（FI-IR）和热重分析法（TGA）对包合物进行表征，进一步验证包合物是否形成。结果表明，包合物以β-环糊精为最佳包合材料，饱和水溶液法为最佳方法，此方法具备载药量和包封率高、节省包合材料和适用于工业化大量生产等优点，其最佳制备工艺条件为：血卟啉与β-环糊精的摩尔比为1:3，搅拌温度是50℃，搅拌时间3h，所得包合物载药量为17。32%，包合率为91。99%。经紫外谱图、红外谱图和热重分析确证了包合物形成。73539
毕业论文关键词 血卟啉 环糊精 包合物 制备 单因素试验 工艺优化
毕业设计说明书外文摘要
Title Study on Preparation Process of Hematoporphyrin and Cyclodextrin Inclusion Compound
Abstract To study the preparation process of the inclution compound of hematoporphyrin and cyclodextrin。 The best cyclodextrin was optimized according to solubility, Drug loading and encapsulation efficiency。 Hematoporphyrin and cyclodextrin inclusion compound was prepared by saturated aqueous solution method and grinding method, the best preparation process was optimized with single factor experiment, and was characterized by ultraviolet spectroscopy (UV), Fourier infrared spectroscopy (FI-IR) and thermal gravimetric analysis (TGA)。 The results showed that inclution compound was prepared with β-cyclodextrin，and the best method was saturated aqueous solution method。 The advantages were high Drug loading and encapsulation efficiency, saving conclution materials and applying to mass production for industrialization。 The optimum preparation conditions of satur- ated aqueous solution method were as follow :the ratio of Hematoporphyrin to cyclodextrin was 1:3, stirring temperature was 50℃, stirring time was 3 h。 Drug loading was 17。32% , encapsulation efficiency was 91。99%。 Hematoporphyrin- cyclodextrin inclusion compound was formed by character。
Keywords Hematoporphyrin cyclodextrin inclusion preparation
single factor experiment process optimization
目 次
1 绪论 1
1。1 环糊精的概述 1
1。1。1 环糊精的结构特点 1
1。1。2 环糊精的性能 2
1。1。3 环糊精形成包合物的条件 2
1。1。4 环糊精作为药物载体的优势 2
1。2 血卟啉的概述 2
1。2。1 血卟啉的结构性质 3
1。2。2 血卟啉的应用 3
1。3 研究内容 3
2 血卟啉-环糊精包合物制备工艺 4
2。1 实验材料及仪器 4
2。1。1 实验材料 4
2。1。2 实验仪器